Simulasi Farmakokinetika Komprehensif

WAKTU SEJAK DOSIS PERTAMA

T+ 00:00

Rute

Dosis

Jumlah dosis

Interval (jam)

Durasi (jam)

Jam dosis pertama

Kecepatan putar

Diminum setelah makan + Penghambat enzim CYP (CL_int × 0,3)

Fungsi hati (CL_int)

Fungsi ginjal

Fraksi bebas (f_u)

Roda tetikus = zoom · seret = geser · klik organ = fokus · tombol 0–7 = organ · spasi = putar/jeda.

Shargel, L., & Yu, A. B. C. (2016). Applied Biopharmaceutics & Pharmacokinetics (7th ed.). McGraw-Hill.
Rowland, M., & Tozer, T. N. (2010). Clinical Pharmacokinetics and Pharmacodynamics (4th ed.). Lippincott Williams & Wilkins.
Holford, N. H. G., & Sheiner, L. B. (1981). Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models. Clinical Pharmacokinetics, 6(6), 429–453.
Sheiner, L. B., Stanski, D. R., Vozeh, S., Miller, R. D., & Ham, J. (1979). Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clinical Pharmacology & Therapeutics, 25(3), 358–371.
Wilkinson, G. R., & Shand, D. G. (1975). A physiological approach to hepatic drug clearance. Clinical Pharmacology & Therapeutics, 18(4), 377–390.

Parameter obat bersifat ilustratif untuk pembelajaran, bukan untuk menentukan dosis pasien.

obat induk

terikat albumin

metabolit

granul belum larut